I quote parts of this Reddit answer.
The easiest way to understand a little calculus is to sit in the middle seat and look at the speedometer in the car. What speed does it say? Maybe it says 31 miles per hour. This means that, if you keep traveling at this speed, you'll go 31 miles in an hour. Any kid can understand that (even if the kid doesn't really know how far a mile is). But then your dad slows down and stops at a red light. The speed is 0 miles per hour now. Did you actually go 31 miles in an hour? No; 31 miles per hour was your speed only at that instant in time. Now the speed is different. The idea that it even makes sense to have a speed at an instant in time is... calculus! You calculate speed by seeing how far you go and dividing by how long it took you to get there, but that only gives you average speed. For the speed right now, you have to see how far you go in a very, very, very tiny amount of time. You only go a very, very, very tiny distance. And you divide by that very, very, very tiny amount of time to get a speed in numbers that you understand. Calculus is when you make that amount of time tinier and tinier and tinier, and that makes the distance tinier and tinier and tinier too, so that, at that moment, the tiny distance divided by the tiny time is 31 miles per hour, but a second later it might be 30 mph or 32 mph or something else.
You generally use calculus to talk about how fast things change -- in the case of the car, it's how fast your position changes, but lots of things can change. How fast something is changing right now is called the derivative. Sometimes you know how the rate of change for something is related to other things. For example, if you have a weight on a spring, you can write how fast the speed of the weight is changing based on its position on the spring, and you can write an equation called a differential equation.
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You can also use calculus to talk about how lots of little things can add up to a big thing. For example, let's say you have an object, and you want to know how much it weighs. You can break it up into tiny little pieces, figure out the density for each piece, figure out how much each little piece weighs, and add them all together. That's calculus! (Or you can just put it on a scale -- that's physics.)
The calculus of how fast things change is called differential calculus, and the calculus of adding up lots of little things is called integral calculus. In differential calculus, you take a tiny little number and divide by another tiny little number to get a regular-sized number. In integral calculus, you add together a very, very, very large number of tiny little numbers to get a regular-sized number.