There are a lot of computation problems in Bhargav Bhatt's Problem Set 1 of Perverse Sheaves 2015, which trouble me a lot.
Basically, suppose $F\colon\mathcal C\to\mathcal D$ is a functor between categories and $\mathcal S$ is the class of morphisms in $\mathcal C$ whose image in $\mathcal D$ is an isomorphism, then $F$ induces a functor $\tilde F\colon\mathcal S^{-1}\mathcal C\to\mathcal D$.
I want to know how to compute $\mathcal S^{-1}\mathcal C$ generally so I think maybe properties of $\tilde F$ will be helpful, especially discovering the conditions under which $\tilde F$ is fully faithful.
I'm looking forward to general strategies, strong enough to solve many questions there: For example, compute $\mathcal S^{-1}\mathcal C$ when $\mathcal C$ is the category of abelian groups and $F=-\otimes_{\mathbb Z}\mathbb Q$. (In general, torsion free abelian groups aren't free, this confuses me a lot), or when $ \mathcal C$ is the category of coherent $\mathscr O_X$ modules over a projective variety $X$ and $F$ is the global section functor.