Incomplete answer, response to your "Any ideas?"
First two ideas which come up are combinatorics and induction.
Combinatorics: How many circles are possible? (A lot).
Every three non-collinear points define a circle. So there are $\begin{pmatrix}{2n+1\\ \ \ \ \ 3} \end{pmatrix}$ distinct circles possible = $ \frac{(2n+1)(2n)(2n-1)}{3!}$ = $\frac{8n^3 - 2n}{6}$ distinct circles.
$n = 0 \ \ $ gives only one point and no circles so is not reasonable given the question constraints.
$n = 1 \ \ \rightarrow 2n+ 1 = 3\ $ so there is one circle with zero points inside and zero outside, correct.
$n = 2 \ \ \rightarrow 2n+ 1 = 5$ so there are $\begin{pmatrix}{5\\ 3} \end{pmatrix} = 10 \ $ distinct circles possible. Two points are not on the circle.
We want to show that one of these circles has one detached point in the interior and one in the exterior.
I don't have a definitive answer yet but am considering something with triangles: If ABC define a circle they also define a triangle. Anything interior to the triangle is also interior to the circle. Careful, exterior is not always true. But given two line segments AD and BE intersecting at C, anything interior to triangle ABC and circle ABC is exterior to triangle DEC and circle DEC.
With $n = 2$ and five points there are $\begin{pmatrix}{5\\2} \end{pmatrix} = 10 \ $ lines possible. An argument could be made about points either side of each line. To consider.
Induction: The case for $n = 1$ forms a base step and if you can prove the case for $n = 2$ you have a methodology; then work inductively adding two points.