The total number of points that the student scores is $75+86+72+S$. The total number of points that the student could have scored is $100+100+100+150 = 450$. Therefore, we must have
$\frac{75+86+72+S}{450} \geqslant 0.80 \,\, \Longrightarrow \,\, S \geqslant 127$
in order for the student to score an overall grade of at least eighty percent. Combining this with the fact that $S \leqslant 150$, we deduce $127 \leqslant S \leqslant 150$.
Why does this work - there was no wieghting involved? In a way there was, but to convince ourselves we got it correct, let's solve the problem again from a different perspective.
Let $p_1 = p_2 = p_3 = \frac{100}{450}$ and $p_4 = \frac{150}{450}$ so that $p_1 + p_2 + p_3 + p_4 = 1$. These are the respective weights for the four exams.
Moreover, we let $X_1,X_2,X_3,X_4$ be the respective percentages scored for the four exams - in particular,
$X_1 = \frac{75}{100}, \,\, X_2 = \frac{86}{100}, \,\, X_3 = \frac{72}{100}$, and $X_4 = \frac{S}{150}$.
Then the solution should be gotten from
$0.80 \leqslant X_1p_1 + X_2p_2 + X_3p_3 + X_4p_4$,
which I claim is the exact same inequality we arrived at before. Indeed,
$X_1p_1 + X_2p_2 + X_3p_3 + X_4p_4$
$ = \left( \frac{75}{100}\right)\left( \frac{100}{450} \right) + \left(\frac{86}{100}\right) \left(\frac{100}{450}\right) + \left(\frac{72}{100}\right) \left(\frac{100}{450} \right) + \left(\frac{S}{150}\right) \left(\frac{150}{450} \right)$
$= \frac{75 + 86+72 +S}{450}$.