Try
$$\left[\frac{dy}{dx}\right]^2 = -(y^2 + 1)$$
This equation can have no real solution at all. Proof by contradiction: assume $y(x)$ is a real valued solution. Then $\left[\frac{dy}{dx}\right]^2$ is real as well, but that implies $\sqrt{-(y(x)^2 + 1)}$ is real, yet $y(x)^2 + 1 > 0$ always no matter what real function $y(x)$ is, thus $-(y(x)^2 + 1) < 0$ always and so this square root can never be real. Contradiction.
EDIT: I just throw it into Wolfram, and it looks like all solutions may be real valued at some isolated points -- but isolated points is not a real-differentiable function of a real variable!