I think this really boils down to combinatorics, specifically arrangements. These are really cool questions, and I'm glad you're being asked questions like this in discrete mathematics because they're really interesting and help you hone your analytical skills.
Anyways, on to how to think about this question. It is classic and I'm sure you can find tons of examples of this specific problem being solved. I'm sure you can see that Mississippi (we can ignore case here) is one specific arrangement of $m i^4s^4p^2, miiiisssspp$, or even just $\{m,i,s,p\}$
So, choose any letter. Let's just go left to right. First you're going to fix a spot for the $m$, which can be done 11 ways (Mississippi is an 11 character word). Now, your $i$, you have 10 places left and 4 $i$'s to use. This is going to be $10\choose{4}$, however you're going to need to remove the choices in there that place $i$s together. Now do that same thing for for $6\choose4$ with $s$, and $2\choose2$ for your $p$s.
Hopefully that guides you to understanding the problem a little better. I know in your case specifically we're just talking about the $s$ being together, but Math Stackexchange is about helping you be a better mathematician, so now you have the basic idea of what the question is asking and you can apply the general "no letters touching" to "we only care if one letter is touching itself" $_{lol}$