This depends crucially on the choice of generating set; in fact, as I'll show below, there are size-2 generating sets both with and without (a version of) your property. The observation you need is this, which has nothing to do with Rubik's cubes:
Lemma: Suppose $G$ is a finite group, $H < G$ is an index-2 subgroup, and $S$ is a generating set of $G$ that is disjoint from $H$. Then no $g \in G$ can be written both as a product of an odd number of generators and as a product of an even number of generators.
Proof: The product of an even number of generators is in $H$, and the product of an odd number isn't.
In fact, conversely, you can see that if some generating set has the property claimed in the lemma, then the set of $g \in G$ that can be written as a product of an even number of generators must be an index-2 subgroup that contains none of the generators. So index-2 subgroups are the only things that can produce these parity restrictions.
In the case of the Rubik's cube group $G$, let $H$ consist of operations that (ignoring orientations) are even permutations of both edges and corners. (This is the only index-2 subgroup of $G$; you can prove this by showing it equals the derived subgroup.) None of the standard six generators are in this subgroup, so the standard generating set has the desired property.
On the other hand, suppose $S = \{g, h\}$ generates $G$. At least one of the two is outside of $H$; say $g$ is. Then if $h \in H$, we get another generating set $\{g, gh\}$ with both elements outside of $H$. Conversely, if $h \notin H$, then $\{g, gh\}$ is a generating set with $gh \in H$. So given that $G$ has some 2-element generating set (which it does), it must have some with the parity property and some without.