It is possible to specify (smooth, oriented, compact) four-manifolds with special framed links:
$$I \times \mathbb{R}P^3$$
Such a link is divided in two sublinks, one ordinary link representing the 2-handles (and their attaching curves) and an unlinked, unknotted link representing the 1-handles.
This notation is used e.g. in Eugénia César de Sá, A link calculus for 4-manifolds (1979), and in more modern works like the book by Gompf & Stipsicz (chapter 5.4), where it is attributed to Selman Akbulut (in works from 1977 to 1979), who in turn thanks Robion Kirby and cites his influential A calculus for framed links in $S^3$ (back then yet to appear), which doesn't talk about 1-handles in 4-manifolds though.
What intrigues me is that de Sá and Akbulut don't cite each other, so I'm somehow suspecting that maybe the notion was developed by someone else (Kirby? Rourke?) and de Sá and Akbulut used it without particularly citing it because everyone knew where it came from?.
Or is the situation yet different and Akbulut "only" developed special framed links and de Sá developed "only" the $\Gamma$-moves, which tell are the equivalence transformations of special framed links?
