Let's rewrite the two lines as follows
$$
\begin{gathered}
l_{\,1} :\mathbf{a} + t\,\mathbf{v} = \left( {1, - 2,5} \right) + t\left( {2,1, - 1} \right) \hfill \\
l_{\,2} :\mathbf{b} + t\,\mathbf{v} = \left( {3,4,1} \right) + s\left( {2,1, - 1} \right) \hfill \\
\end{gathered}
$$
so that it is clear the definition of the two points $\mathbf a$ and $\mathbf b$ and vector $\mathbf v$.
Then as you correctly noted, being the vector $\mathbf v$ the same, the lines are parallel.
Consider now the segment joining the points $\mathbf a$ and $\mathbf b$ and the relevant difference vector
$$
\mathbf{c} = \mathbf{b} - \mathbf{a} = \left( {2,6, - 4} \right) = 2\left( {1,3, - 2} \right)
$$
The plane $\pi _{\,//} $ containing the two lines, shall contain both points and be parallel to $\mathbf v$,
i.e. it shall pass by one of the points and be normal to the vector
$$
\mathbf{n} = \mathbf{c} \times \mathbf{v} = \left( { - 2, - 2, - 4} \right) = - 2\left( {1,1,2} \right)
$$
and since the vector $\mathbf n$ is not null, the two lines are distinct.
Now the required plane $\pi _{\, \bot } $ shall clearly be:
- orthogonal to $\pi _{\,//} $, i.e. parallel to $\mathbf n$
- parallel to the lines, i.e. parallel to $\mathbf v$
- equidistant from the lines, i.e. passing through the mid-point of the segment $\mathbf b - \mathbf a$
which means:
- orthogonal to the vector $\mathbf{m} = \mathbf{n} \times \mathbf{v} = \left( { - 3,5, - 1} \right)$
- passing through the point $\left( {\mathbf{b} + \mathbf{a}} \right)/2 = \left( {2,1,3} \right)$
So we get
$$
\pi _{\, \bot } :\left( {x - 2,y - 1,z - 3} \right) \cdot \left( { - 3,5, - 1} \right) = 0
$$