I'll elaborate a bit on my comment. If you have to choose a substitution, you try to make the integral easier to calculate. This can be done by either simplyfing the region of integration (and thus the limits of the variables) or by simplifying the integrand. If you're lucky, you can try doing both.
$\int_{D} \frac{x-y}{1+x+y} d(x,y)$ for $D=\{(x,y)\in\Bbb R^{2}|0
Based on the region $D$, a natural choice would be to go for a substitution of the form:
$$u = x+y \; , \; v = x-y$$
This would not only simplify how the region $D$ is given as a function of the (new) variables ($0 \le u,v \le 1$), it would also simplify the integrand. Note that when performing this substitution, you shouldn't forget the Jacobian. Can you take it from there?