I'll assume all of the coefficients $a_k$ are continuous on the interval of interest $I$.
Theorem: [Existence and Uniqueness] Let $a_0,a_1,\cdots,a_{n-1}$ be fixed constants, and let $t_0$ be a point in the interval of interest $I$ for the ordinary differential equation stated in your problem. Then there exists a unique solution $x(t)$ defined on $I$ such that
$$
x^{(k)}(t_0)=a_k,\;\;\; k=0,1,2,\cdots,n-1.
$$
Proof: Use Picard iteration to establish existence and uniqueness.
Theorem: [Wronskii] Let $\{ x_1,x_2,\cdots,x_n \}$ be a set of solutions of the ODE. The Wronskian $W(x_1,x_2,\cdots,x_n)$ vanishes at some point $t_0$ of the interval of interest $I$ iff $\{ x_1,x_2,\cdots,x_n \}$ is a linearly dependent set of functions on $I$.
Proof: If the set of functions $\{ x_1,x_2,\cdot,x_n \}$ is a linearly dependent set of functions on $I$, then there are constants $\alpha_1,\alpha_2,\cdots,\alpha_n$ such that
$$
\alpha_1 x_1(t)+\alpha_2 x_2(t)+\cdots +\alpha_n x_n(t) = 0,\;\;\; t\in I.
$$
By differentiating this equation $n-1$ times, one obtains the matrix equation
$$
\left[\begin{array}{cccc}
x_1(t) & x_2(t) & \cdots & x_n(t) \\
x_1'(t) & x_2'(t) & \cdots & x_n'(t) \\
\vdots & \vdots & \ddots & \vdots \\
x_1^{(n-1)}(t) & x_2^{(n-1)}(t) & \cdots & x_n^{(n-1)}(t)
\end{array}\right]
\left[\begin{array}{c} \alpha_1 \\ \alpha_2 \\ \vdots \\ \alpha_n\end{array}\right] = 0.
$$
The existence of a non-trivial solutions $[\alpha_j]$ forces the determinant of the coefficient matrix--which is the Wronskian--to vanish for all $t$. Therefore the Wronskian of the solutions $x_1,x_2,\cdots,x_n$ vanishes identically if the solutions are linearly dependent.
Conversely, suppose that the Wronskian $W(x_1,x_2,\cdots,x_n)$ vanishes at some $t \in I$. Then there are constants $\alpha_1,\alpha_2,\cdots,\alpha_n$ such that
the matrix equation of the previous paragraph holds. Hence,
$$
x(t) = \alpha_1 x_1(t)+\alpha_2 x_2(t) + \cdots + \alpha_n x_n(t)
$$
is a solution of your ODE which satisfies $x(t)=x'(t)=\cdots=x^{(n-1)}(t)=0$. By uniqueness of solutions, $x\equiv 0$, which proves that the set of functions $\{x_1,x_2,\cdots,x_n\}$ is a linear independent set of functions. $\blacksquare$
To see that the set of solutions is an n-dimensional vector space, let $S$ be the set of solutions on the interval $I$, and let $t \in I$. Then the map
$$
M : S \rightarrow \mathbb{R}^{n}
$$
defined by
$$
Mx = \left[\begin{array}{c}x(t) \\ x'(t) \\ \vdots \\ x^{(n-1)}(t)\end{array}\right]
$$
is linear. This map is injective because $Mx=0$ iff $x\equiv 0$ by uniqueness of solutions. The map is surjective because of the existence of solutions. So $S$ is $n$-dimensional because $M$ is a linear isomorphism.