Let $\dot{x} = f(x)$ be a dynamical system on $\mathbb{R}^n$ with corresponding flow $\phi(t,x)$ and let $U \subseteq \mathbb{R}^n$ be Lebesgue measurable. Then $$\frac{d}{dt}\int_{\phi(t,U)}dx = \int_{\phi(t,U)}\text{div}(f(x))dx$$
Proof. By the change of variable formula for multiple integrals we have $$\int_{\phi(t,U)}dx = \int_{U}\det(D\phi_t(x))dx$$
This I do not really understand. I mean, we could define a mapping $$U \to \phi(t,x) \qquad x \mapsto\phi(t,x)$$ for which $U$ has to be open (we want a $C^1$-diffeomorphism). But wouldn't we get then $$\int_{\phi(t,U)}dx = \int_{U}|\det(D\phi_t(x))|dx$$ instead of the above? I do not quite see why the determinant should be positive.