If you're talking about Olympiads or related competitions, I think calculus is actually forbidden or at least highly discouraged (if you do not state the theorem exactly or do not verify the assumptions many points will fly away).
In these competitions there is often a proof by Mean inequalities with an ad hoc application. In this case by the inequality between the Arithmetic and the Harmonic Mean
$$\frac{a\!+\!\left(\frac b2\!+\!\frac b2\right)\!+\!\left(\frac c3\!+\!\frac c3\!+\!\frac c3\right)\!+\!\left(\frac d4\!+\!\frac d4\!+\!\frac d4\!+\!\frac d4\right)}{10}\geq \frac{10}{\tfrac1a\!+\!\left(\tfrac2b\!+\!\tfrac2b\right)\!+\!\left(\tfrac3c\!+\!\tfrac3c\!+\!\tfrac3c\right)\!+\!\left(\tfrac4d\!+\!\tfrac4d\!+\!\tfrac4d\!+\!\tfrac4d\right)}$$
from which
$$\frac1a+\frac4b+\frac9c+\frac{16}{d}\geq 100$$
and the equality is achieved, as in every Mean inequality, when all the terms are equal, in this case
$$a=\frac b2=\frac c3=\frac d4.$$
From $a+b+c+d=1$ you can find the exact values $a=\frac{1}{10},b=\frac{2}{10},c=\frac{3}{10},d=\frac{4}{10}$.
EDIT: You can also use Cauchy-Schwartz:
$$\left(\frac{1}{\sqrt a}\sqrt a+\frac{2}{\sqrt b}\sqrt b+\frac{3}{\sqrt c} \sqrt c+\frac{4}{\sqrt d}\sqrt d\right)^2\leq\left(\frac1a+\frac4b+\frac9c+\frac{16}{d}\right)\left(a+b+c+d\right)$$