Is there a way to perform the following differentiation under the line integral sign ?
$$ I = \frac{d}{dt}\left(\int_{\Gamma\left(t\right)}\vec{u}\cdot d\vec{x}\right) $$
provided the vector $ \vec{u}=\vec{u}\left(\vec{x},t\right)$ varies in space and also varies with the variable $ t $. And provided that $ \vec{u} $ may not be conservative.
The curve $\Gamma$ may also be allowed to depend on the variable $ t $ and may even be allowed to undergo translations and rotations. But, the most important thing about $\Gamma$ is that it be an open curve and not a closed one. This is because I know that the closed curve would be a special case of the 2-D Liebnitz rule.
Is there a general formula for this operation ? and, if so, how could one prove it?