This question doesn't seem complete because you need to have some additional constraints on the coefficients of the polynomial for this to have one answer.
I am going to assume your question means $a, b, c, d, e \in \mathbb{R}$. In this case, since it is a 4th degree polynomial, it is of the form
$$
ax^4 + bx^3 + cx^2 + dx + e = (x-z_1)(x-z_2)(x - z_3)(x - z_4)
$$
where $z_1, z_2, z_3, z_4$ are the roots of the polynomial. We already know two of these so we have:
$$
\begin{align}
z_1 &= 2 - i \\
z_3 &= 1 + 3i
\end{align}
$$
Now since the coefficients are real, the roots must come in conjugate pairs i.e. for every complex root $z = \alpha+\beta i$, there must be another root $\overline{z} = \alpha - \beta i$ so that $(x-z)(x-\overline{z})$ will cancel out their imaginary parts, resulting in real coefficients. Thus:
$$
\begin{align}
z_2 &= \overline{z_1} = 2 + i \\
z_4 &= \overline{z_3} = 1 - 3i \\
\end{align}
$$
So your polynomial is:
$$
\begin{align}
ax^4 + bx^3 + cx^2 + dx + e &= (x-z_1)(x-z_2)(x - z_3)(x - z_4) \\
&= (x- 2 + i)(x- 2 - i)(x - 1 - 3i)(x - 1 + 3i) \\
&= x^4 - 6 x^3 + 23 x^2 - 50 x + 50
\end{align}
$$
Matching coefficients on the LHS and RHS, we get:
$$
\begin{align}
a &= 1 \\
b &= -6\\
c &= 23\\
d &= -50 \\
e &= 50
\end{align}
$$