Assume $p$ is prime and $p\ge 3$.
Through experimentation, I can see that it's probably true. Using Wilson's theorem and Fermat's little theorem, it's equivalent to saying $2^2 4^2 6^2 \cdots (p-1)^2 = (-1)^{\frac{p+1}{2}}$ mod $p$, but I can't figure out any more than that.