Begin with
${y_n}(x) = {x^{n - 1}}{e^{1/x}}$
Then, taking the first derivative, we get
${y_n}'(x) = \left( {n - 1} \right){x^{n - 2}}{e^{1/x}} - {x^{n - 3}}{e^{1/x}}$
This is
$\tag{1}{y_n}'(x) = \left( {n - 1} \right){y_{n - 1}(x)} - {y_{n - 2}}(x) $
You then get
${y_n}''(x) = \left( {n - 1} \right)y{'_{n - 1}}(x) - y{'_{n - 2}}(x)$
so you have to use $(1)$ to obtain that exclusively in terms of $y_n$.
You can do this for a couple of terms, conjecture a general formula, and prove it by induction. In fact, the formula will be only in terms of $n!/(n-k)!$ and $y_{n-k}$, it seems. When you get a general formula for $y_n^{(k)}$, you can plug in $n$ and get the formula you want.
Another option would be
$\eqalign{ & {y_n}' = \left( {n - 1} \right)\frac{1}{x}{x^{n - 1}}{e^{1/x}} - \frac{1}{{{x^2}}}{x^{n - 1}}{e^{1/x}} \cr & {y_n}' = \left( {n - 1} \right)\frac{1}{x}{y_n} - \frac{1}{{{x^2}}}{y_n} \cr & {y_n}^\prime (x) = \left( {n - 1} \right)\left( {\frac{1}{x} - \frac{1}{{{x^2}}}} \right){y_n} \cr} $
Then
${y_n}''(x) = \left( {n - 1} \right)\left( { - \frac{1}{{{x^2}}} + \frac{2}{{{x^3}}}} \right){y_n} + \left( {n - 1} \right)\left( {\frac{1}{x} - \frac{1}{{{x^2}}}} \right)y{'_n}$
So
${y_n}''(x) = \left( {n - 1} \right)\left( { - \frac{1}{{{x^2}}} + \frac{2}{{{x^3}}}} \right){y_n} + {\left( {n - 1} \right)^2}{\left( {\frac{1}{x} - \frac{1}{{{x^2}}}} \right)^2}{y_n}$
But it seems much more complicated, due to the repeated use of the product rule and chain rule involved.