We do not know it in some sense, but taking Platonic stance we actually know it for sure. Assume that there exists a totality of standard natural numbers, say $\mathfrak{N}$. Suppose $\varphi$ is the Goldbach conjecture, which is $\Pi_1$ sentence (begins with a universal unbounded quantifier followed be a formula expressing recursive property or realtion). Finally suppose that you managed to show that neither $PA\vdash\varphi$ nor $PA\vdash\neg\varphi$ (where $PA$ is first-order Peano arithmetic).
However, as a Platonist I believe that either $\varphi$ is true about $\mathfrak{N}$ or it is false about it. Assume it is false, which entails that its negation must be true. But $\neg\varphi$ is equivalent to a $\Sigma_1$ formula (truly) asserting existence of a natural number which is not a sum of two primes: $\exists_x\psi(x)$. Take this (standard) number, say $n$, and substitute $\overline{n}$ for $x$ to obtain $\psi(\overline{n})$ which asserts a recursive property of $n$. From representability of recursive properties you obtain that $PA\vdash\psi(\overline{n})$, so $PA\vdash\exists_x\psi(x)$, so $PA\vdash\neg\varphi$, contrary to the fact that $\varphi$ is undecidable. (The mehtod described applies to all $\Pi_1$ sentences and uses so called $\Sigma_1$ completeness of $PA$)
Of course the hard part is proving undecidability of $\varphi$, and as it was said by Robert Israel in the comments above, this would probably be a longer way than challenging Goldbach conjecture directly. Moreover being Platonist is not enough as well, since you must engage some (stronger than $PA$) theory in which you can carry a proof of independence of $\varphi$.
Thus reception of a proof of this kind would probably rely on nature of methods applied in showing undecidability of the conjecture. Last but not least, constructivists could attack the assumption about definite truth value of the conjecture or (maybe even more likely) the part in which one infers existence of $n$ from a premiss saying: not every natural number... .